Premature ejaculation (PE) is a distressing male sexual dysfunction that can be present from the first sexual encounter or can develop later in life. Men with PE appear to go through the same process of ejaculation as other men, but it happens more quickly and with a reduced feeling of control. A combination of physiological and psychological factors are believed to impact on ejaculatory latency, and research suggests that serotonin plays a central role. The negative consequences of PE are significant: they cause sexual dissatisfaction, personal distress, interpersonal difficulty, low self-esteem, and they may affect partner satisfaction. For treating premature ejaculation we recommend you to try Priligy (Dapoxetine).
This product is a selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation. SSRIs have been shown to be effective for the treatment of PE. The downside to most SSRIs is that they must be taken daily in order to achieve the desired effect. Dapoxetine was designed to be taken on an "as needed" basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that dapoxetine increases the intra-vaginal ejaculation latency time (IELT) - the time from vaginal penetration to male orgasm.
Posology and method of administration
Adult men (aged 18 to 64 years)
The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. Treatment with Priligy should not be initiated with the 60 mg dose.
Priligy is not intended for continuous daily use. Priligy should be taken only when sexual activity is anticipated. Priligy must not be taken more frequently than once every 24 hours.
If the individual response to 30 mg is insufficient and the patient has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as needed approximately 1 to 3 hours prior to sexual activity. The incidence and severity of adverse events is higher with the 60 mg dose.
If the patient experienced orthostatic reactions on the starting dose, no dose escalation to 60 mg should be performed.
A careful appraisal of individual benefit risk of Priligy should be performed by the physician after the first four weeks of treatment (or at least after 6 doses of treatment) to determine whether continuing treatment with Priligy is appropriate.
Data regarding the efficacy and safety of Priligy beyond 24 weeks are limited. The clinical need of continuing and the benefit risk balance of treatment with Priligy should be re-evaluated at least every six months.
Elderly (age 65 years and over)
The efficacy and safety of Priligy have not been established in patients age 65 years and over.
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